O1-02-02: A NEGATIVE FLORBETABEN PET SCAN RELIABLY EXCLUDES AMYLOID PATHOLOGY AS CONFIRMED BY HISTOPATHOLOGY
نویسندگان
چکیده
منابع مشابه
Cardiac Amyloid Imaging with 18F-Florbetaben PET: A Pilot Study.
Our aim was to determine the feasibility of 18F-florbetaben PET in diagnosing cardiac amyloidosis. METHODS 18F-florbetaben PET was performed on 14 patients: 5 amyloid light chain, 5 amyloid transthyretin, and 4 control with hypertensive heart disease. Qualitative and quantitative assessments of 18F-florbetaben activity were performed using the SUVmean of the left ventricular myocardium and bl...
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BACKGROUND Positron emission tomography (PET) images with amyloid tracers show normal uptake in healthy white matter, which suggests that amyloid tracers are potentially useful for studying such white matter diseases as multiple sclerosis (MS). METHODS Twelve patients diagnosed with MS (5 with RRMS, 5 with SPMS, and 2 with PPMS) and 3 healthy controls underwent studies with MRI and (18)F-flor...
متن کاملFlorbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study
BACKGROUND Evaluation of brain β-amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease (AD) and other dementias. METHODS Open-label, nonrandomized, multicenter, phase 3 study to validate the (18)F-labeled β-amyloid tracer florbetaben by comparing in vivo PET imaging with post-mortem histopathology. RESULTS Brain images and tissue from 74 dece...
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Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative that was developed as a positron emission tomography (PET) tracer for routine clinical application to visualize β-amyloid plaques in the Alzheimer's disease (AD) brain. The tracer successfully completed a global multicenter phase 0-III development program and was, as a consequence, recently approved by the US Food and Drug Administr...
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BACKGROUND D-Dimer, a cross-linked fibrin degradation product, has a high sensitivity in patients with suspected venous thrombosis. Traditional latex D-dimer assays, however, have not been sufficiently sensitive to exclude venous thromboembolism. METHODS To determine the clinical utility of a latex D-dimer assay (MDA D-Dimer; Organon Teknika Corporation, Durham, NC) in patients with suspected...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2014
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2014.04.063